Intravenous anesthesia

Abstract

Anesthesia and Pain Medicine. 2003 Dec. 7(4): 144-149
ⓒ Korean Society for Intravenous Anesthesia
  
 
 
Effect Site Concentration at the Point of Patient\'s Need for Sedation in Patient Controlled Sedation with Propofol
Sang Mook Lee, M.D. and Keon Jung Yoon, M.D.
Department of Anesthesiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
 

BACKGROUND: Patient controlled sedation (PCS) using propofol has been reported to be safe and effective. However, the effect site concentration at the point of patient\'s need for sedation has not been reported. The effect site is the theoretical compartment in which a drug exerts its action and the concentration at this site is a direct determinant of a drug\'s effect. The aim of this study was to define the effect site concentration in patient controlled sedation with propofol.
METHODS: Twenty patients scheduled to undergo lower leg operation with spinal anesthesia. Propofol PCS was performed with bolus dose 0.5 mg/kg without basal infusion and check the effect site concentration and BIS (bispectral index) at the point of patient\'s need for sedation. Vital signs, effect site concentration, BIS, SpO2, sedation score and infusion rate were checked as time followed.
RESULTS: The effect site concentration and BIS at the point of patient\'s needs for sedation were 1.31 0.12 mug/ml and 82.0 3.6. Administrated dose of propofol is 4.18 1.42 mg/kg/hr. The change of effect site concentration and BIS during perioperative period had no significant values as time.
CONCLUSIONS: Effect site concentration at the point of patient\'s needs sedation is useful for supplement of anesthesiologist controlled sedation.
 
Key words : Effect site concentration, patient controlled sedation, phamacokinetics, propofol
중심단어 :