Intravenous anesthesia

Abstract

Anesthesia and Pain Medicine. 2004 June 8(2): 122-128
ⓒ Korean Society for Intravenous Anesthesia
  
 
 
The Effect of Small Dose Ketamine on Postoperative Pain After Video-Assisted Thoracoscopic Sympathectomy: Influences of Dose and Timing of Injection
Hyun Kyoung Lim, M.D., Sang Kee Min, M.D.*, Jin Soo Kim, M.D.*, Jong Yeop Kim, M.D.*, Hyo Jin Byon, M.D., and Choon Soo Lee, M.D.
Department of Anesthesiology and Pain Medicine, College of Medicine, Inha University, Inchon, Korea, *Department of Anesthesiology and Pain Medicine, College of Medicine, Ajou University, Suwon, Korea
 

Background: Ketamine may produce preemptive analgesia when administered before surgically induced trauma, but the reliability of preemptive analgesia is controversial. The purpose of this study was to assess whether dose and timing of intravenous ketamine could affect the postoperative pain and analgesic requirement.
Methods: Sixty-patients undergoing video-assisted thoracoscopic sympathectomy were randomly divided into five group according to dose and timing of IV ketamine. The patients received either ketamine 0.15 mug/kg before surgical incision and saline 5 ml after incision (K15pre group); saline before incision and ketamine 0.15 mug/kg after incision (K15post group); ketamine 0.5 mug/kg before incision and saline after incision (K50pre group); ketamine 0.5 mug/kg before incision and saline after incision (K50post group); or saline before and after incision (control group). The general anesthetic technique was standardized in all five groups.
Results: During the second and third postoperative hour, all groups experienced significantly less pain than during the first postoperative hour, as assessed by using both numeric rating and Prince Henry scales. There were no significant differences among the groups with respect to pain scores, postoperative analgesic requirements, and incidences of postoperative nausea and vomiting.
Conclusions: In this study, IV ketamine 0.15 or 0.5 mug/kg did not reduce postoperative pain scores and analgesic requirements regardless of dose and timing of injection.
 
Key words : Ketamine, postoperative pain, preemptive analgesia
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