Intravenous anesthesia


Anesthesia and Pain Medicine. 2004 Dec. 8(4): 197-202
ⓒ Korean Society for Intravenous Anesthesia
Effect of 1% and 2% Propofol on Blood Lipids during Target Controlled Infusion for Anesthesia in Surgery of Moderate Duration
Sung Yong Park, M.D., Sang Ki Min, M.D., Sook Young Lee, M.D., Jong Yeop Kim, M.D., Jae Hyung Kim, M.D., Seung Hee Baeck, M.D., and Jin-Soo Kim, M.D.
Department of Anesthesiology and Pain Medicine, College of Medicine, Ajou University, Suwon, Korea

Background: Propofol is a short-acting intravenous anesthetic agent commonly used for induction and maintenance of surgical anesthesia and for sedation in the intensive care unit. Because propofol is water insoluble, current formulations use a soybean oil emulsion. Soybean emulsion causes elevated plasma triglyceride. The purpose of this study was to compare the effects of 1% and 2% propofol on the lipid levels during target controlled infusion for anesthesia in surgery of moderate duration.
Methods: Sixty patients scheduled for orthopedic surgery were included and randomly allocated to group 1 (infusion of 1% propofol) or group 2 (infusion of 2% propofol). Anesthesia was induced and maintained by the computer-controlled infusions of 1% or 2% propofol. Plasma lipid concentrations and hemodynamic profiles were evaluated.
Results: The elevations of plasma triglyceride concentrations were significantly larger in group 1 than group 2. The changes of plasma cholesterol concentrations and hemodynamic profiles were no significant difference between two groups.
Conclusions: Our results suggested that plasma triglyceride concentrations increase significantly in 1% propofol group than 2% propofol. Thus 2% propofol may be preferable to the 1% propofol for induction and maintenance of anesthesia in surgery of moderate duration.
Key words : Complications, formulations, hyperlipidemia, propofol
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