Intravenous anesthesia


Anesthesia and Pain Medicine. 2006 June 10(2): 55-59
ⓒ Korean Society for Intravenous Anesthesia
Comparison of the Effects of Dexamethasone Alone, versus Dexamethasone Plus Ondansetron on Postoperative Vomiting in Children Undergoing Tonsillectomy
Jong Yeon Lee, M.D., Ji Hoon Kim, M.D., and Chung Hyun Park, M.D.
Department of Anesthesia and Pain Medicine, College of Medicine, Pochon CHA University, Pocheon, Korea

Background: Postoperative vomiting (POV) is common problem following tonsillectomy in children. We compare the effect of adding ondansetron to dexamethasone on POV after tonsillectomy. Methods: Seventy eight children 2⁣15 years of age undergoing tonsillectomy were studied. Thirty seven children were randomly assigned to receive 0.1 mg/kg up to 5 mg dexamethasone (Group D) and 41 children were received the same dose of dexamethasone plus 0.05 mg/kg of ondansetron (Group OD). All patients were assessed for the incidence of POV and adverse effect (headache, dizziness, sedation, constipation) at recovery room (0 to 1 h) after surgery and 12 h, 24 h after surgery. Results: The incidence of POV in Group D was 16.2% (6/37) compared with 2.4% (1/41) in Group OD at recovery room after surgery (P < 0.05). There were no differences in the incidences of POV at 12 h, 24 h after surgery between two groups and no significant differences in the adverse effects between two groups. Conclusions:The combination of dexamethasone and ondansetron is more effective than dexamethasone alone in reducing the incidence of POV at recovery room after surgery in children undergoing tonsillectomy.
Key words : dexamethasone, ondansetron, postoperative vomiting (POV), tonsillectomy.
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