Abstract
| Anesthesia and Pain Medicine. 2006 June 10(2): 55-59 ⓒ Korean Society for Intravenous Anesthesia |
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| Comparison of the Effects of Dexamethasone Alone, versus Dexamethasone Plus Ondansetron on Postoperative Vomiting in Children Undergoing Tonsillectomy |
| Jong Yeon Lee, M.D., Ji Hoon Kim, M.D., and Chung Hyun Park, M.D. |
| Department of Anesthesia and Pain Medicine, College of Medicine, Pochon CHA University, Pocheon, Korea |
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| Background: Postoperative vomiting (POV) is common problem following tonsillectomy in children. We compare the effect of adding ondansetron to dexamethasone on POV after tonsillectomy. Methods: Seventy eight children 215 years of age undergoing tonsillectomy were studied. Thirty seven children were randomly assigned to receive 0.1 mg/kg up to 5 mg dexamethasone (Group D) and 41 children were received the same dose of dexamethasone plus 0.05 mg/kg of ondansetron (Group OD). All patients were assessed for the incidence of POV and adverse effect (headache, dizziness, sedation, constipation) at recovery room (0 to 1 h) after surgery and 12 h, 24 h after surgery. Results: The incidence of POV in Group D was 16.2% (6/37) compared with 2.4% (1/41) in Group OD at recovery room after surgery (P ＜ 0.05). There were no differences in the incidences of POV at 12 h, 24 h after surgery between two groups and no significant differences in the adverse effects between two groups. Conclusions:The combination of dexamethasone and ondansetron is more effective than dexamethasone alone in reducing the incidence of POV at recovery room after surgery in children undergoing tonsillectomy. |
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| Key words : dexamethasone, ondansetron, postoperative vomiting (POV), tonsillectomy. |
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