Intravenous anesthesia


Anesthesia and Pain Medicine. 2005 Dec. 9(4): 205-210
ⓒ Korean Society for Intravenous Anesthesia
The Effect of Ramosetron and Metoclopramide on the Bispectral Index and Awakening Time
Chul Ho Shin, M.D., Young Woo Cho, M.D., Dae Woo Kim, M.D., and Keon Kang, M.D.
Department of Anesthesiology and Pain Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea

Background: Ramosetron lacks the sedative, extrapyramidal symptoms associated with metoclopramide and droperidol. Sedation can occurs in patients receiving metoclopramide and delayed recovery from anaesthesia has been reported. Our study was designed to compare the effect of ramosetron with metoclopramide on the bispectral index (BIS) and awakening time.
Methods: Forty four patients scheduled for elective operation were allocated at random into two groups: ramosetron 0.3 mg or metoclopramide 10 mg. These drugs were administered intravenously before completion of the surgical procedure. Postoperative nausea and vomiting (PONV) were recorded within the first 48 hour after surgery. BIS, blood pressure, heart rate before and after injection of antiemetics, and awakening time were obtained.
Results: There was no significant difference in the incidence of PONV between ramosetron and metoclopramide group. In the metoclopramide treated group, the BIS value significantly decreased from 46.6+/-7.3 to 39.6+/-10.2 in 12-15 minutes after injection (P<0.05). There was no significant difference in the awakening time between the two groups.
Conclusions: The BIS was decreased significantly in the metoclopramide treated group but there was no difference in awakening time between the two groups.
Key words : bispectal index (BIS), extrapyramidal symptoms, metoclopramide, postoperative nausea and vomiting (PONV), ramosetron.
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