Intravenous anesthesia


Anesthesia and Pain Medicine. 2005 Dec. 9(4): 197-204
ⓒ Korean Society for Intravenous Anesthesia
The Effects of Preincisional Low-dose Ketamine and Fentanyl in Addition to General Anesthesia on the Analgesia for Postoperative Pain
Ja Yoon Tae, M.D., Hee Jung Baik, M.D., Eun Young Yu, M.D., Yun Jin Kim, M.D., and Jong Hak Kim, M.D.
Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womens University, Seoul, Korea

Background: We evaluated the preemptive analgesic effect of small dose of ketamine and fentanyl given before the surgical incision performed in patients undergoing spinal surgery with general anesthesia and the effect on the analgesia for postoperative pain.
Methods: The thirty three patients undergoing spinal surgery were randomly allocated into three groups which received normal saline (group I) or 0.15 mg/kg of ketamine (group II) or 0.15 mg/kg of ketamine and 1mug/kg of fentanyl (group III), 5 minutes before the surgical incision. All the patients received intravenous patient-controlled analgesia with morphine-ketorolac mixture, which was started at the time of skin closure. Verbal numerical scale (VNS) pain score, cumulative total analgesic consumptions, and side effects were recorded at 1, 3, 6, 12, 24 and 48 h postoperatively.
Results: The VNS pain score and the number of rescue dose of analgesics required at postoperative 1 h were significantly decreased in goup II and III compared to goup I (P<0.05). However, there were no significant differences in VNS in other time points, and total morphine consumption and side effects among three groups.
Conclusions: The low doses of ketamine and fentanyl which were given before the surgical incision were effective for early postoperative pain within 1 hour in patients undergoing spinal surgery
Key words : fentanyl, general anesthesia, intravenous patient controlled analgesia, ketamine, preemptive analgesia.
중심단어 :