Intravenous anesthesia


Anesthesia and Pain Medicine. 2005 Dec. 9(4): 185-190
ⓒ Korean Society for Intravenous Anesthesia
The Effects of Nimodipine on Rocuronium-Induced Neuromuscular Blockade Using a Rat Phrenic Nerve-Hemidiaphragm Preparation
Yun Jin Kim, M.D.
Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womans University, Seoul, Korea

Background: The interaction between nimodipine, a calcium channel blocker, used for the treatment of subarachnoid hemorrhage, and rocuronium, was studied in rat phrenic nerve-hemidiaphragm preparation.
Methods: A square wave 0.1 Hz supramaximal stimuli was applied to a rat phrenic nerve-hemidiaphragm preparation and the twitch height response was recorded mechanomyographycally. We measured cumulative concentration response curves of rocuronium, and ED5, ED50, ED90, and ED95 of rocuroniumwere calculated using an inhibitory sigmoid Emax model after pretreating with different concentrations of nimodipine 5, 50, 500 ng/ml, respectively.
Results: The dose-response curve of rocuronium was significantly shifted to the left in the nimodipine 500 ng/ml (P< 0.05) (Fig. 1) and pretreated nimodipine (500 ng/ml) significantly reduced ED5, ED50, ED90, and ED95 of rocuroniumcompared with control (P<0.05) (Table 1).
Conclusions: We concluded that nimodipine will increase the sensitivity to rocuronium in the phrenic nerve-hemidiaphragm preparation of the rats.
Key words : calcium channel blocker, interaction, nimodipine, phrenic nerve-hemidiaphragm prepara- tion, rocuronium.
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