Abstract
| Anesthesia and Pain Medicine. 2006 Mar. 10(1): 23-30 ⓒ Korean Society for Intravenous Anesthesia |
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| The Effects of Intravenously Infused Amrinone on Arterial Oxygenation during Opened Chest and One Lung Venitlation in Supine Position |
| Jong Yeon Park, M.D., Jae Woong Choi, M.D., and In Cheol Choi, M.D. |
| Department of Anesthesiology and Pain Medicine, College of Medicine, University of Ulsan, Seoul Asan Medical Center, Seoul, Korea |
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| Background: The effects of amrinone on oxygenation are not well known. We have studied the effects of amrinone on oxygenation during one lung ventilation in supine position. Methods: Twenty four patients scheduled for coronary artery bypass graft and one-lung ventilation were randomly assigned to control or amrinone group. Each group was consisted of 4 steps measuring hemodynamic and oxygenation parameters. Step 1; two-lung ventilation (TLV), Step 2; one-lung ventilation (OLV), Step 3; OLV with amrinone continuous infusion (0.5 mg/kg loading dose followed by 5μg/kg/min continuous infusion), Step 4; TLV with amrinone continuous infusion. In the control group, normal saline was infused instead of amrinone. Parameters were checked at the end of 30 minutes after starting each step. Results: OLV produced significant decreases in partial pressure of arterial oxygen and pulmonary shunt fraction but significant increases in alveolar-arterial oxygen pressure difference (P ＜ 0.05). Amrinone did not produce further changes in hemodynamic and oxygenation parameters. Conclusions: We suggest that amrinone (0.5 mg/kg loading dose followed by 5μg/kg/min continuous infusion) may not significantly influence on arterial oxygenation and shunt fraction during OLV in supine position. |
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| Key words : amrinone, hypoxic pulmonary vasoconstriction, one lung ventilation. |
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