Intravenous anesthesia


Anesthesia and Pain Medicine. 2006 Mar. 10(1): 23-30
ⓒ Korean Society for Intravenous Anesthesia
The Effects of Intravenously Infused Amrinone on Arterial Oxygenation during Opened Chest and One Lung Venitlation in Supine Position
Jong Yeon Park, M.D., Jae Woong Choi, M.D., and In Cheol Choi, M.D.
Department of Anesthesiology and Pain Medicine, College of Medicine, University of Ulsan, Seoul Asan Medical Center, Seoul, Korea

Background: The effects of amrinone on oxygenation are not well known. We have studied the effects of amrinone on oxygenation during one lung ventilation in supine position. Methods: Twenty four patients scheduled for coronary artery bypass graft and one-lung ventilation were randomly assigned to control or amrinone group. Each group was consisted of 4 steps measuring hemodynamic and oxygenation parameters. Step 1; two-lung ventilation (TLV), Step 2; one-lung ventilation (OLV), Step 3; OLV with amrinone continuous infusion (0.5 mg/kg loading dose followed by 5μg/kg/min continuous infusion), Step 4; TLV with amrinone continuous infusion. In the control group, normal saline was infused instead of amrinone. Parameters were checked at the end of 30 minutes after starting each step. Results: OLV produced significant decreases in partial pressure of arterial oxygen and pulmonary shunt fraction but significant increases in alveolar-arterial oxygen pressure difference (P < 0.05). Amrinone did not produce further changes in hemodynamic and oxygenation parameters. Conclusions: We suggest that amrinone (0.5 mg/kg loading dose followed by 5μg/kg/min continuous infusion) may not significantly influence on arterial oxygenation and shunt fraction during OLV in supine position.
Key words : amrinone, hypoxic pulmonary vasoconstriction, one lung ventilation.
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