Intravenous anesthesia


Anesthesia and Pain Medicine. 2002 June 6(2): 72-76
ⓒ Korean Society for Intravenous Anesthesia
BACKGROUND: Ascorbic acid has cellular protective and antioxidant effects in ischemic-reperfusion model. This randomized double blind study was conducted to investigate the effects of ascorbic acid pretreatment in the elective knee arthroscopic surgery.
Wha Ja Kang, Keon Sik Kim
Department of Anesthesiology, College of Medicine, Kyunghee University, Seoul, Korea

BACKGROUND: Patients infected with Staphylococcus aureus (S. aureus) related the use of propofol have been reported. The purpose of this study was to assess and compare the growth of S. aureus in thiopental, midazolam, ketamine, propofol or a 1 : 1 mixture of propofol and thiopental.
METHODS: These intravenous anesthetics were innoculated with S. aureus and they were plated onto blood agar at 0, 3, 6, 21, 24 and 27 h. The number of colony forming units (CFU) on the plate was counted after 24 h of incubation.
RESULTS: Samples from ketamine and midazolam showed no CFU at the 3 h and there after. The 6 h, thiopental exhibited no CFU. The innoculated propofol emulsion showed a significant increase in number of CFU at the 21, 24 and 27 h compared with the zero time (P < 0.05). The 1 : 1 mixture of propofol and thiopental showed a significant decrease in number of CFU at the 6, 21, 24 and 27 h compared with the zero time (P < 0.05). These counts were also significantly lower than the number of CFU in propofol at the same time periods (P < 0.05).
CONCLUSIONS: This study has shown that a 1 : 1 mixture of thiopental and prppofol does not support the growth of the staphylococcus aureus and it may reduce the risk of postsurgical infections associated with propofol.
Key words : Anesthetics, Intravenous, propofol, thiopental, midazolam, ketamine, Infection
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