Intravenous anesthesia


Anesthesia and Pain Medicine. 2002 June 6(2): 66-71
ⓒ Korean Society for Intravenous Anesthesia
The Effect of Ascorbic Acid on Skeletal Muscle Metabolites in the Knee Arthroscopic Surgery Using Tourniquet
InSuk Kwok, WanHo Roh, MinJae Son, HeeWok Wie, TaeHyung Han, KwangMin Kim
Department of Anesthesiology and Pain Medicine, HanGang Sacred Heart Hospital, Hallym University, School of Medicine, Seoul, Korea

BACKGROUND: Ascorbic acid has cellular protective and antioxidant effects in ischemic-reperfusion model. This randomized double blind study was conducted to investigate the effects of ascorbic acid pretreatment in the elective knee arthroscopic surgery.
METHODS: Forty patients, scheduled for the elective knee arthroscopic surgery, were equally divided into two groups by coin-flip method. One hour before the scheduled surgery, one group (n = 20) received ascorbic acid 1,000 mg in 100 ml of normal saline and the other group with plain normal saline (n = 20). Initial blood sample was obtained before the tourniquet inflation for the baseline value. Serial samples were gathered at 5, 10, 30 and 60 minutes immediately after the tourniquet release. Measured parameters were electrolytes (K , Ca2 , Na ), glucose, uric acid, pH, PVO2, PVCO2, and muscle enzymes (LDH, CPK, AST). Demographic data were analyzed with Paired t-test. For the comparison of parameters within and between groups, repeated measures of ANOVA were applied.
RESULTS: Between the two groups, significant differences were noted in the levels of venous oxygen tension at 30 minutes and muscle enzymes at 10 and 30 minutes, which recovered within an hour.
CONCLUSIONS: In our study, 1,000 mg of Vitamin C pretreatment shows no preventive effect in the release of muscle metabolites after the deflation of tourniquet.
Key words : Arthroscopy, Electrolytes, Enzyme, Ischemia, Ascorbic acid
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