Intravenous anesthesia


Anesthesia and Pain Medicine. 2002 June 6(2): 55-59
ⓒ Korean Society for Intravenous Anesthesia
Does Intraoperative Injection of Ephedrine, Epinephrine and Phenylephrine Influence the Bispectral Index during Enflurane Anesthesia?
Hye Won Shin, Hye Won Lee, Byung Cheol Shin, Hun Cho, Hae Ja Lim, Suk Min Yoon, Seong Ho Chang
Department of Anesthesiology and Pain Medicine, College of Medicine, Korea University, Seoul, Korea

BACKGROUND: In some studies, catecholamine intravenous infusion was claimed to enhance the Bispectral index (BIS) and awakening in sedated patients. We investigated the effect of intravenous ephedrine, epinephrine or phenylephrine on the BIS during enflurane anesthesia.
METHODS: Thirty patients (ASA class I or II, 23 59 yrs) for elective upper abdominal surgery were randomly allocated into three groups (ephderine, epinephrine, phenylephrine group). The patients with history of cardiovascular or cerebrovascular diseases were excluded in this study. After induction with 5 mg/kg of thiopental and 0.1 mg/kg of vecuronium for tracheal intubation, anesthesia was maintained with enflurane 1 MAC with O2 2 L/min-Air 2 L/min. After stabilization of BIS, intravenous ephedrine 10 mg, epinephrine 10 microgram or phenylephrine 100 microgram was injected during maintenance. Mean arterial pressure (MAP), heart rate (HR) and BIS were measured at the baseline period and every one minute interval for 10 minutes after intravenous injection of drug. The data were analyzed with repeated measured ANOVA (P < 0.05).
RESULTS: Some increase of MAP and HR were noticed after injection of ephedrine and epinephrine. Some increase of MAP and decrease of HR were noticed after injection of phenylephrine. There was no significant change in BIS after intraveous injection of ephedrine, epinephrine, and phenylephrine respectively.
CONCLUSIONS: During enflurane anesthesia, intravenous catecholamines would not increase the BIS.
Key words : Bispectral index, catecholamines, enflurane
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