Intravenous anesthesia


Anesthesia and Pain Medicine. 2002 Sept. 6(3): 148-152
ⓒ Korean Society for Intravenous Anesthesia
Effect of Lidocaine on Injection Pain of Propofol: Difference of Method of Injection and Injection Sites
Jung-won Hwang, Younsuk Lee, Yong Seok Oh
Department of Anesthesiology, Hanil General Hospital, Seoul, Korea.,Department of Anesthesiology, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea.,Department of Anesthesiology, Seoul National University, Seoul, Korea.

BACKGROUND: Pain on injection with propofol is a common problem. The vein is smaller, the pain is more severe. To prevent pain, we injected lidocaine as a pretreatment or a mixed solution with propofol. To evaluate the effect of lidocaine to prevent injection pain of propofol, the severity and incidence of pain was compared according to injection sites, and between pretreatment and mixed solution respectively.
METHODS: We selected 282 adult patients with 18 G intravenous catheter on upper extremity. Without premedication, they were randomly allocated to three groups. In group C, only 100 mg of propofol was injected, 30 mg of lidocaine was pretreated in group L, and 30 mg of lidocaine was mixed with propofol in group M. In all groups, propofol was injected at a speed of 1 cc a second. We checked the incidence and the severity of injection pain (no pain, mild, severe).
RESULTS: The incidence of injection pain were 56.5%, 43.2%, and 13.8% (Group C, L, and M). In group M, the incidence and severity of injection pain was lowest. In group L, propofol injection via a vein of dorsum of hand was less painful compared with group C (64.7% vs 94.1%).
CONCLUSIONS: The results of this study showed that both the incidence of and the severity of pain with propofol injection is dependent on the method of injection of lidocaine and the injection sites. To prevent propofol injection pain, it is recommended to mix with lidocaine just before injection via large vein.
Key words : Anesthetics, intravenous, propofol, Anesthetics, local, lidocaine, Pain, injection
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