Intravenous anesthesia


Anesthesia and Pain Medicine. 2002 Dec. 6(4): 214-219
ⓒ Korean Society for Intravenous Anesthesia
Optimal Dose of Propofol and Changes of Spontaneous Respiration during Outpatient Anesthesia Using Propofol and Fentanyl
Tae Jung Kim, M.D., Jang Ho Song, M.D., Choon Soo Lee, M.D., Hyun Kyoung Lim, M.D., Seong Keun Lee, M.D., Je Dong Oh, M.D., Ji Sun Park, M.D., Young Deog Cha, M.D.,
Department of Anesthesiology and Pain Medicine, College of Medicine, Inha University, Incheon, Korea.

BACKGROUND: Propofol (2,6-diisopropylphenol) is becoming the intravenous anesthetic of choice for ambulatory surgery. The aim of this study was to evaluate optimal propofol infusion rate during short gynecological procedures, and to evaluate respiratory and cardiovascular effects of 3 different propofol infusion rate.
METHODS: Sixty nine outpatients (ASA 1, 2) scheduled for gynecological procedures were randomly allocated into three groups. After receiving 2 microgram/kg of fentanyl intravenously, the patients received an initial bolus of propofol of 2 mg/kg and then a continuous infusion at a rate of 100 microgram/kg/min (Group 1 [n=23]), 120 microgram/kg/min (Group 2 [n=23]), and 150 microgram/kg/min (Group 3 [n=23]). Apneic time, patient\'s movement, respiratory rate, mean arterial pressure, pulse rate, and peripheral O2 saturation were recorded during the continuous infusion of propofol. The rescue dose of propofol 50 microgram/kg/min was added when operation was difficult due to patient\'s movement.
RESULTS: Apneic time was not significantly different among the three groups. During propofol infusion, the decrease in respiratory rate lasted for 6, 9 and 12 minutes in group 1, 2 and 3, respectively. The number of patients who move during operation in the group 3 was significantly lower than that of the group 1.
CONCLUSIONS: After induction with propofol 2 mg/kg and fentanyl 2 microgram/kg, optimal infusion rate of propofol is more than 150 microgram/kg/min for adequate operating condition. The faster infusion rate produced the longer duration of decreased respiration rate.
Key words : Apnea,fentanyl, gynecologic, outpatients anesthesia, propofol
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