Intravenous anesthesia


Anesthesia and Pain Medicine. 2002 Dec. 6(4): 200-205
ⓒ Korean Society for Intravenous Anesthesia
The Effect of Basal Infusion during Patient Controlled Sedation with Propofol
Kyemin Kim, M.D., Woo Yong Lee, M.D., Seung Hoon Woo, M.D., Younsuk Lee, M.D., Jun Heum Yon, M.D., Ki Hyuk Hong, M.D.
Department of Anesthesiology, Sanggye Paik Hospital, Inje University, College of Medicine, Seoul, Korea

BACKGROUND: Patient controlled sedation (PCS) using propofol has been reported to be safe and effective during procedures performed under locoregional anesthesia. However, the role of basal infusion on the efficacy of PCS has not been documented. The purpose of this study was to evaluate the effect of PCS with basal infusion on sedation score and patient\'s satisfaction during regional anesthesia.
METHODS: Twenty-eight healthy patients undergoing procedures under regional anesthesia were enrolled in this study. In group I (n = 14), propofol PCS was performed with bolus dose 0.5 mg/kg, lockout time 1 minute without basal infusion. In group II (n = 14), propofol PCS was performed with bolus dose 0.5 mg/kg, lockout time 1 minute with basal infusion at the rate of 50 microgram/kg/min. The depth of sedation was assessed with OAA/S scale, and patient\'s satisfaction was assessed with numerical rating scale. Side effects such as ventilatory depression and hypoxemia were treated and recorded.
RESULTS: The depth of sedation was significantly deeper in group II. There were no differences between groups in satisfaction scores and the incidence of side effects.
CONCLUSIONS: When compared with PCS only group, the basal infusion of propofol at the rate of 50 g/kg/min combined with propofol PCS leads to deeper sedation without affecting patient\'s satisfaction. Conclusively, the addition of basal infusion to PCS has little benefit.
Key words : Propofol, patient controlled sedation, regional anesthesia
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